Prolonged Mild Hypothermia Therapy Protects the Brain Against Permanent Focal Ischemia
نویسندگان
چکیده
منابع مشابه
Prolonged mild hypothermia therapy protects the brain against permanent focal ischemia.
BACKGROUND AND PURPOSE The efficacy of hypothermic intervention for permanent focal ischemia has yet to be clarified. This study investigated the effect of a prolonged moderate or mild hypothermia on permanent focal ischemia in rats. METHODS Two permanent focal ischemia models in male Sprague-Dawley rats were used. Moderate (30 degrees C, in experiment 1) or mild (33 degrees C, in experiment ...
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Microglia are macrophage-like phagocytic cells in the brain parenchyma. However, microglial function after neurodegeneration is not fully understood. In this study, occlusion of the middle cerebral artery (MCA) and reperfusion caused massive neuronal loss in the rat cerebral cortex and striatum after 3 days. When exogenous microglia were microinjected into the intracerebroventricle during MCA o...
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BACKGROUND AND PURPOSE Both hypothermia and decompressive craniectomy (DC) have been shown to reduce ischemic injury in experimental middle cerebral artery (MCA) infarction. This study was designed to evaluate the effect of combined DC and hypothermia on infarction size and neurological outcome in a rat model of MCA occlusion (MCAO). METHODS MCAO was performed in 72 Wistar rats assigned to gr...
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ژورنال
عنوان ژورنال: Stroke
سال: 2001
ISSN: 0039-2499,1524-4628
DOI: 10.1161/01.str.32.1.232